Src SH3 domain

Fig. 9.3 shows the results of this experiment on the c-Src SH3 domain carried out as a two-dimensional H(N)CO where only amide proton and carbonyl 13C frequencies were... 

Exploring the leucine-proline binding pocket of the Src SH3 domain using structure-based, split-pool synthesis and affinity-based selection. /. Am. Chem. Soc. 1998, 120, 30-36. 

Cheadle C, Ivashechenko Y, South Y, Searfoss G, French S, Howk R, Ricca G, Jaye M, Identification of a Src SH3 domain binding motif by screening a random phage display library, J. Biol. Client., 269 24034-24039, 1994,... 

Combs, A.P., Kapoor, T.M., Feng, S.B., Chen, J.K., Daudesnow, L.F. and Schreiber, S.L. Protein Structure-Based Combinatorial Chemistry Discovery ofNon-Peptide Binding Elements To Src SH3 Domain. J.Am. Chem. Soc., 1996,118,287-288. 

Dezelee, R Barnier, J.V. Hampe, A. Laugier, D. Marx, M. Galibert, E Calothy, G. Small deletion in v-src SH3 domain of a transformation defective mutant of Rous sarcoma virus restores wild type transforming properties. Virology, 189, 556-567 (1992)... 

Schreiber and collaborators proposed a split-pool combinatorial chemistry approach based on the combination of three consecutive members of a library of 32 monomers with the C-terminal portion of an ideal Src class I proline-rich moiety (PLPPLP) (190, 191). The ligands, whose general structure is thus Cap-monomer 1-monomer 2-monomer 3-PLPPLP, were selected using the Src-SH3 domain. The tightest binding member in the set of isolated molecules interacted with the Src-SH3 with a Kq of 3.4 pM. A solution structure of this complex revealed the structural basis of interaction (71). As expected, the ligand binds as a class I... 

Erpel, T, Superti-Furga, G., and Courtneidge, S. A. (1995). Mutational analysis of the Src SH3 domain the same residues of the ligand binding surface are important for intra-and intermolecular interactions. EMBO J. 14, 963-975. 

Wildes, D., Marqusee, S. (2005) Hydrogen exchange and ligand binding Ugand-dependent and ligand-independent protection in the Src SH3 domain. Protein Science, 14 (1), 81-88. 

The coefficients and rjct are for single-input (AG) neural networks. Ibe a-spectrin SH3 domain values are those for pH 7 the src SH3 domain values are for pH 6. TTie X-repressor values ate for 2M urea. 

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