Sponges dictyostatin

Dictyostatin [90a] Due to its exceptional biological profile as a promising anticancer agent at nanomolar concentrations, tremendous efforts have been devoted to the synthesis of dictyostatin (131). Indeed, this natural product that was extracted from a sponge from the Indian Ocean by Pettit et al. 

Isbrucker RA, Cummins J, Pomponi SA, Longley RE, Wright AE. Tlibulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin. Biochem. Pharmacol. 2003 66(l) 75-82. 

Paterson, I., Britton, R., Delgado, 0., and Wright, A.E. (2004) Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp. Chem. Commun., 632-633. 

Paterson, I, Britton, R, Delgado, 0, Meyer, A, and Poullennec, K.G. (2004) Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin. Angew. Chem. Int. Ed., 43,4629-4633. 

---