Spleen sialidase

Sialidase-treated erythrocytes from rats, unlike the normal erythrocytes, preferentially adhered to mononuclear spleen cells and Kupffer cells of the liver. This recognition manifests itself, both in autologous and homologous systems, by the adhesion of complementary cells in the form of rosettes. This process may be the normal physiological mechanism for removing circulating erythrocytes that have a decreasing proportion of sialic acid residues. 

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