Spleen poly , isolation

Although there are substantial amount of data available on responses to synthetic poly(amino acids) which are essentially pseudo-biological polymers, a survey of literatures has provided information mostly on PVP. For example, Andersson and coworkers (6) have shown that PVP can induce Ab production in adult thymectomized mice after irradiation, followed by reconstitution with B-cells isolated from the spleens of other non-treated mice with the same genetic background. Their experiment demonstrates that PVP is a T-independent Ag (O. Further studies have shown that such response in reconstituted mice is affected by the maturity of the B-cells, and in younger animals, the co-operation of T-cells is required (7 ). In addition, others have observed that low doses of PVP may stimulate a sub-population of T-cells (the helper cells) to... 

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