Spiders and wasps

Polyamine toxins from spiders and wasps. In The Alkaloids, vol. 45, eds. G. Cordell and A. Brossi, pp. 1-125. New York Academic Press. 

A. L. Mueller R. Roeloffs H. Jackson, Pharmacology of Polyamine Toxins from Spiders and Wasps. In Alkaloids (San Diego), G. A. Cordell, Ed. Academic Press San Diego, CA, London, 1995 Vol. 46, pp 63-94. 

The continuing interest in the polyamine amides as lead structures comes at a time of major changes in the insecticide industry, not least of which is a reappraisal of the so-called rational approach towards insecticide discovery. This may slow industrial research on these compounds. Also, developments involving natural products as starting points are being examined very critically by environmentalists and the polyamine amide toxins have not escap their attention. It has been suggested that the use of polyamine amide insecticides could lead to resistance to the natural products present in the venoms of spider and wasp. However, the potential consequences of this for the ecosystem in general are difficult to identify, let alone to estimate. 

Keywords Ionotropic glutamate receptors Natural products Nicotinic acetylcholine receptors Polyamine toxin Solid-phase synthesis Spider and wasp... 

Chemical Synthesis of Spider and Wasp Polyamine Toxins... 

Mueller AL, Roeloffs R, Jackson H (1995) Pharmacology of polyamine toxins from spiders and wasps. In Cordell GA (ed) The alkaloids chemistry and pheumacology, vol 46. Academic... 

Saito M, Kawai N, Miwa A, Pan-Hou H, Yoshioka M (1985) Spider toxin (JSTX) blocks glutamate synapse in hippocampal pyramidal neurons. Brain Res 346 397-399 Schafer A, Benz H, Fiedler W, Guggisberg A, Bienz S, Hesse M (1994) Polyamine toxins from spiders and wasps. In Cordell GA, Brossi A (eds) The alkaloids chemistry and pharmacology,... 

---