Sphingolipids sphingosine

P-1,1 -sphingosine)] (sphingolipid) Sphingosine (= 1,3- animals likely to be in plants Universal named after the SPH-R (weak) —... 

Kihara A, Mitsntake S, Mizntani Y, Igarashi Y. Metabolism and biological fnnctions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog. Lipid Res. 2007 46 126-144. 

Figure 26.3. Synthesis of Sphingolipids. Sphingosine is converted into ceramide, which is an intermediate in the formation of sphingomyelin and gangliosides.

Sphingophospholipids, 30 see also Sphingolipids Sphingosine bases, 281 Sphingosine, 311 Spinach, 163-65,488 Sponge lipids, 5 Spray reagents, 277 Spreading pressure, 338 Squalene, 138,144,148 Squalus acanthus, 138 Squid, 137... 

ANALYZE THE PROBLEM sphingomyelin sphingolipid sphingosine palmitic acid (16 0) phosphate and choline as an ionized amino alcohol amide bond to palmitic acid phosphoester bond to sphingosine and to choline ... 

Fig. 14.—Schematic Representation of the Fragmentation Observed in the Positive F.a.b.-Mass Spectrum of a Permethylated Ganglioside Isolated from Granulocytes. [Other glyco-sphingolipids fragment in a similar way. Major cleavages are shown with solid lines, and minor cleavages with dotted lines. The masses of ions resulting from cleavages (a), (b), and (c) define the type of sphingosine and the type of fatty acid. In this example, (a) is 548, (b) is [M + H] minus 238, and (c) is [M + H] minus 533.]...

Figure 22.6 Sphingolipids are constructed of sphingosine derivatives containing an acylated fatty acid and a head group attached to the hydroxyl.

Glycerolipids are derivatives of glycerol and fatty acids 34 In sphingolipids, the long-chain aminodiol sphingosine serves as the lipid backbone 37... 

Sphinganine is acylated, then dehydrogenated to form ceramide. Free sphingosine, also termed sphingenine, salvaged from sphingolipid breakdown can be enzymatically acylated with acyl-CoA to form ceramide. 

Figure 12.12 Sphingomyelins. Sphingomyelins are esters of a ceramide and phospho-ryl choline. However, similar compounds are ceramide-1-phosphoryl ethanolamines and phosphono forms of sphingolipids. Ceramides W-acyl-sphingosines) are amides of a long chain di- or trihydroxy base containing 12 to 22 carbon atoms, of which sphingosine (4-sphingenine) is the commonest, and a long chain fatty acid whose acyl chain is shown by R1. This may contain up to 26 carbon atoms.

Attachment of another long-chain fatty acid in an amide linkage to the amino group of sphingosine forms a ceramide, the parent compound for many of the physiologically important sphingolipids. 

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