Speed up Reactions by Lowering the Free Energy of Activation

Catalysts Speed up Reactions by Lowering the Free Energy of Activation 

Equation (12) indicates that, if AG is greater than zero as is I most often the case, a reaction can be sped up either by [ decreasing AG or by raising the temperature. Little can I usually be done to change k0. For living organisms, it gener- 

An enzyme speeds up a reaction by decreasing AG. The enzyme does not change the free energy of the substrate (S) or product (P) it lowers the free energy of the transition state. The two vertical arrows indicate the activation free energies (AG ) of the catalyzed and uncatalyzed reactions. 

It should be kept in mind that although an enzyme can increase the rate at which a reaction occurs, it (or any other catalyst) cannot alter the overall equilibrium constant. Since A gq is equal to the ratio of the rate constants for the forward and reverse processes, the catalyst increases both of these rate constants without changing their ratio. 

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A Critical Amount of Energy Is Needed for the Reactants to Reach the Transition State Catalysts Speed up Reactions by Lowering the Free Energy of Activation Kinetics of Enzyme-Catalyzed Reactions... 

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