Specification sheet physical parameters

Alternatively by submitting certificates of analysis of the active ingredient received from the original source and from the second source covering all the parameters listed in the product specification sheet and substantive data regarding physical and chemical parameters (e.g., polymorphism, chirality, solvates, etc., where relevant). 

The manufacture specifies a number of physical parameters on the specification sheet. The user has no option but to accept these figures. However, they will be critical when setting up mathematical models such as MCNP programs and ISOCS (see Chapter 7, Section 7.7). The measurements will have been made with the detector at room temperature and un-mounted. Therefore, some laboratories have found it necessary to X-ray their detector while cooled in order to measure the physical parameters at operating temperature. There have been surprises detectors mounted off-centre, for example A useful trick when making such measurements is to stick a small piece of carefully measured platinum wire to the side of the detector cap. The image of this will be very clear on the X-ray and provide a reference distance. 

It is assumed that process conditions and physical properties are known and the following are known or specified tube outside diameter D, tube geometrical arrangement (unit cell), shell inside diameter D shell outer tube limit baffle cut 4, baffle spacing and number of sealing strips N,. The effective tube length between tube sheets L may be either specified or calculated after the heat-transfer coefficient has been determined. If additional specific information (e.g., tube-baffle clearance) is available, the exact values (instead of estimates) of certain parameters may be used in the calculation with some improvement in accuracy. To complete the rating, it is necessary to know also the tube material and wall thickness or inside diameter. 

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