Specific non-immunological effects

Liver halogenated hydrocarbons (e.g., carbon tetrachloride, tetrachloroethane, chloroform), ethanol, 1,1,1-trichloroethane, trichloroethylene, bromobenzene, dimethylformamide acute (necrosis, steatosis) and chronic (cirrhosis) hepatotoxic symptoms 

Kidney halogenated hydrocarbons (e.g., carbon tetrachloride), toluene, dioxane, diethylene glycol, ethylene glycol, glycol ethers, conjugates of trichloroethylene acute tubular necrosis, glomerular and tubular dysfunctions (e.g., albuminuria, proteinuria), glomerulonephritis, note modification of solvent effects caused by renal dysfunctions possible 

Reproductive system carbon disulfide, benzene, glycol ethers, nitrobenzene disturbance of menstrual cycle reduced sperm counts, embryotoxic effects 

Hemopoietic system benzene metabolites (e.g., benzoquinone, hydroquinone) marrow depression, myelotoxic effects 

Nerval system n-hexane, ethanol, styrene, tetrachloroethylene peripheral neuropathy (especially distal axons, axon swelling and degeneration, loss of sensibility, muscular atrophy, loss of tendon reflexes) 

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