Specific loss

Tram-anular interactions, which would create an active radical site via hydrogen transfer through 98, cannot be invoked to explain the specific loss of a CH3 radical from the ether side chain. This conclusions is based upon the following experimental observations. The radical cation of the tetrafluoro substituted compound 101 eliminates CH3, but loss of CH3 from the para-isomer 102 is not observed. If a transanuiar process according to 97- 98 were operative, then such a reaction is not expected to be suppressed upon substitution of H by F as is known for many examples from the field of photochemistry of fluoro substituted compounds41 (23). 

The loss of isobaric neutral species from the molecular ions of isomeric nitroanisoles has been studied using deuterium labelling74. The mass analysis indicated that specific loss of CH2O occurs from the molecular ions of 2-nitroanisole, while a specific loss of NO takes place from 3-nitroanisole74. Although the peak due to [M —NO]+ is neglectible in the MS of 2-nitroanisole, it is apparently an important transient intermediate in the consecutive fragmentation of the molecular ions. 

In this connection, a specific loss of hypoxanthine-quanine phosphoribosyltransferase activity has been observed in cases of gout associated with the overproduction of uric acid [305] and in a neurological disorder, the Lesch-Nyhan syndrome [306]. Although a causal relationship has not been established, these disorders could be indicative of the importance of these enzymes. 

Technique-specific loss of microorganisms can be estimated by comparing the recovery in the diluting fluid A group to the inoculum count. 

C) In Ref. 79 the phenomenon of ion rattling motions was supposed to influence the recorded absorption band at v > 200 cm-1. It seems that without a theory capable of describing the whole 0- to 1000-cm 1 band it is hardly possible to assign the measured alteration of absorption due to a number of specific physical factors. The model, presented above, can be used as a basis for this purpose. However, to achieve this aim, a few important factors should additionally be accounted for. (a) It appears that first of all it is reasonable to introduce an additional fraction containing water molecules of a hydration sheath around an ion. The dielectric response of this fraction should differ from that of bulk water, (b) A model of an ion-dipole system suggested by the authors in GT, p. 318, could possibly be employed for this studies, (c) Another important task concerns development of a model describing the specific loss mechanism due to vibration of H-bonded molecules. 

The rates of the loss of OH and OD from the molecular ion of benzoic acid C6D5COOH have been determined over the time range 10 ps to 10ps [521]. There was specific loss of OH- at times less than about 60 ps, but at longer times, both OH and OD were lost. The temperature of the wire appeared to affect the proportions of OH- and OD- lost (both at 10 ns—lps and at 10ps), with higher temperatures increasing the... 

Popken GJ, Bunney WE, Jr., Potkin SG, Jones EG. 2000. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics. Proc Natl Acad Sci USA 97 9276-9280. 

The direct analysis of oxide products such as iron-sinter, slag or refractories, leads to considerably non-specific loss of light due to the large silicate matrix. It has yet to be investigated whether the use of background correction will make direct oxide analysis possible. 

Thus, weight loss associated with exercise becomes more specifically loss of body fat (60). 

Two observations suggest near normal function for rcel cells. First, loss of Rcelp minimally impacts hematopoiesis in otherwise normal tissue [46]. Second, adoptive transfer of murine rcel fetal liver cells rescues hematopoiesis in lethally irradiated mice. Moreover, tissue-specific loss of Rcelp in liver also results in otherwise healthy mice, as judged histologically and biochemically (i.e., transaminase activity) [11]. These... 

Gilad Y, Man O, Paabo S, Lancet D. Human specific loss of olfactory receptor genes. Proc. Natl. Acad. Sci. U.S.A. 2003 100 3324-3327. 

Fischer A, Gilad Y, Man O, Paabo S. Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 2005 22 432-436. Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics 2005 170 313-326. 

---