Specific Complications of Intrathoracic Sarcoidosis

Mechanism(s) responsible for PAH in sarcoidosis include hypoxic vasoconstriction (117), infiltration or obliteration of pulmonary vessels by the granulomatous, fibrotic response (96,118), and extrinsic compression of major pulmonary arteries by enlarged lymph nodes (96). A retrospective study of 22 patients with sarcoidosis and PAH found that mPAP correlated inversely with 

Other rare vascular complications of sarcoidosis (limited to a few case reports) include pulmonary arterial stenoses from granulomatous involvement of the vessels, extrinsic compression of pulmonary arteries by enlarged hilar lymph nodes or fibrosing mediastinitis (6), pulmonary veno-occlusive disease (resulting from obstruction of interlobular septa veins by granulomata or perivascular 

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