Special Topic Other Synthetic Routes to Acid Derivatives

FIGURE 18.50 Ketenes react with nucleophiles to give acyl compounds. 

12 Special Topic Other Synthetic Routes to Acid Derivatives 

As mentioned in the introduction to this chapter, reactions and syntheses are even more intertwined than usual with these acid derivatives. A reaction of one is a synthesis of another. The various interconversions of acyl compounds discussed in this chapter (and in Chapter 17) are summarized in Section 18.15. Here we first discuss two rearrangement reactions that are useful as syntheses of esters and amides, respectively, then move on to a brief discussion of routes to nitriles and ketenes. 

12a The Baeyer-Villiger Reaction Named by Kurt Mislow (p. 152) for Adolf von Baeyer (p. 187) and his student Victor Villiger (1868-1934), the Baeyer-Villiger reaction is an oxidation of aldehydes and ketones, usually with a 

CHAPTER 18 Derivatives of Carboxyiic Acids Acyi Compounds 

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