Special Aspects of Bioseparation

Biomolecular separation requires different techniques than chemical separations. Biological molecules are sensible to heat and solvents, which can destabilize the three-dimensional structure of proteins resulting in loss of the molecule s function (Carta and Jungbauer, 2010). 

2 Sanitary Design and Sanitization Sanitary design is necessary to ensure hygienic performance and thorough cleaning standard column attributes to minimize bacterial contamination are listed below  

For proof of cleanabUity column suppliers need to provide data of how the equipment performs under bacterial challenge. An example of bacterial challenge is expressed in the next paragraph. 

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