Spasmogenic activity inhibition

ML antispasmodic activities are inhibition of the contraction of intestine using cholinomimetic as spasmogen. 

Chloroform extracts of dried feverfew leaves produced reversible constructions of vascular smooth muscle, while ones of fresh leaves caused an irreversible, non-specific inhibition of contractility. It is shown that chloroform extracts contain substances which inhibit voltage-dependent K+ currents by an open channel-blocking mechanism. This effect could account for the spasmogenic action and antimigraine activity, and be related to the lactone content [154,215,229]. 

Ethanol and aqueous extracts of B. crassifolia bark have also been reported to have good anti-inflammatory activity in the HET-CAM and the cyclooxygenase inhibition assays as well as antimicrobial activity [86, 87, 88]. In addition, we reported that the leaf and bark extracts of B. crassifolia displayed concentration-dependent, spasmogenic effects on rat... 

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