Soybean phytoestrogens cancer

Hetman, C. T. Adiercreutz B.R. Goldin S.L. Gorbach K.A.V. Hbekerstedt. Soybean phytoestrogen intake and cancer risk./. Nutr. 1995, 125, 757S. 

Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK, Markkanen MH, Makela TH, Whala KT, Hase TA, Fotsis T. Soybean phytoestrogen intake and cancer risk. J Nutr 1995 125(suppl) 757S-770S. 

Glycine max (L.) Merrill G. soja Sieb. Zucc. Da Dou Ye Da Dou (Soybean) (seed) Protein, isoflavone derivatives, genisteine, daidzein, riboflavin, thiamine, niacin, pantothenic acid, choline.33,67 Phytoestrogenic, elevate the vasomotor system, prevent cancer, a potent inhibitor of protein tyrosine kinase. 

Isoflavones are flavonoids commonly called as phytoestrogens and one of the most extensively investigated polyphenols. These are present in soybeans, soybean products, and other pulses, widely consumed in Asian and Southeast Asian coim-tries. Isoflavones have attracted attention mainly due to their role in the ameliora-ti(Mi of postmenopausal symptoms such as hot flushes and osteoporosis [52,58,59]. The other beneficial and important biological properties have been established which are related to effects on cardiovascular diseases, cognitive functions, and breast and prostate cancers. These conclusions were based on wide-ranging studies and parameters which showed positive effects, for example, reduction of hot flushes, the excretion of Ixme resorption markers, increase in bone mineral density, the lower LDL and total cholesterol, reduction in colon cancer, and modulation of immune function [60, 61]. Chemical structures of some important molecules of these phytochemical classes are represented in Fig. 82.3. 

The incidence of breast and prostate cancer is much higher in Western covmtries than in Far Eastern ones, where there is an abundance of dietary phytoestrogens. Populations in the Far East have been consuming soyabean for centuries. In contrast. Western cultures and diets have only started to adopt soy foods much more recently. Western-style soy foods are produced by modem processing techniques in large soybean-processing plants. 

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