SoxR gene

SoxR, OxyR Fur LAC9 Acel —rather uniform results showing activation -de-repression of genes that are under the control of Fur —attenuated DNA-binding in vitro —inhibition of DNA-binding in yeast... 

NADH, reduced nicotinamide-adenine dinueleotide Q, coenzyme Q FNR, fumarate nitrate reduction SoxR, superoxide activated regulatory protein IRP, iron regulatory protein NIFU, nitrogen fixation gene U product. 

In procaryotes, short upstream regulatory sequences (generally less than 100 bp) known as antioxidant response elements (AREs) control the expression of antioxidant enzymes. In E. coli, up-regulation of SODs involves soxR and soxS gene products [69]. 

The studies of bacterial oxidative stress responses have been very important in several respects. The oxyR and soxRS systems show how dynamic modulation of gene expression can help counteract both metabolic oxidants and oxidative stress imposed by environmental agents. These systems have potential importance in aspects of clinical infections, as noted above. More broadly, the molecular characterization of OxyR and of SoxR have provided key models for understanding how transcrip-... 

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