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Sorbitol spray-dried

Spray Drying. Spray-dry encapsulation processes (Fig. 7) consist of spraying an intimate mixture of core and shell material into a heated chamber where rapid desolvation occurs to thereby produce microcapsules (24,25). The first step in such processes is to form a concentrated solution of the carrier or shell material in the solvent from which spray drying is to be done. Any water- or solvent-soluble film-forming shell material can, in principle, be used. Water-soluble polymers such as gum arable, modified starch, and hydrolyzed gelatin are used most often. Solutions of these shell materials at 50 wt % soHds have sufficiently low viscosities that they stiU can be atomized without difficulty. It is not unusual to blend gum arable and modified starch with maltodextrins, sucrose, or sorbitol. [Pg.321]

Instant sorbitol is made by spray drying a concentrated aqueous solution of sorbitol [2]. [Pg.465]

Bauer H, Herkert T, Bartels M. 2000. Investigations on polymorphism of mannitol/sorbitol mixtures after spray drying using different scanning calorimetry, X-ray diffraction and near infrared spectroscopy. Pharm. Ind. 62(3) 231-235. [Pg.201]

Fig. 11 Sugar alcohols. Mannitol, crystalline (A), mannitol, spray dried (B), and sorbitol-instant, spray dried (C). Fig. 11 Sugar alcohols. Mannitol, crystalline (A), mannitol, spray dried (B), and sorbitol-instant, spray dried (C).
Tablets. SEM was widely used to investigate the structure of tablets. An excellent review is presented by Hess. " Imaging of tablets is a useful tool to demonstrate differences in compression behavior of substances. Fig. 24 shows an example where the plastically deforming spray-dried sorbitol instant was compressed together with the more brittle ascorbic acid in one tablet. At low compressional force of 5 kN for a 10 mm tablet, the rectangular ascorbic acid crystals as well as the partially deformed sorbitol particles are visible (Fig. 24A). In Figs. 24A and B, the surfaces of two tablets compressed at 5 kN and 30 kN are compared. At higher compressional forces, a uniform, flat, and smooth tablet surface is formed, but within this surface a single unchanged ascorbic acid crystal could be detected. Observation of a broken tablet (Fig. 24C), which was prepared at a high compressional force of 30 kN, reveals that the ascorbic acid crystal is totally fixed within a matrix of plastically... Tablets. SEM was widely used to investigate the structure of tablets. An excellent review is presented by Hess. " Imaging of tablets is a useful tool to demonstrate differences in compression behavior of substances. Fig. 24 shows an example where the plastically deforming spray-dried sorbitol instant was compressed together with the more brittle ascorbic acid in one tablet. At low compressional force of 5 kN for a 10 mm tablet, the rectangular ascorbic acid crystals as well as the partially deformed sorbitol particles are visible (Fig. 24A). In Figs. 24A and B, the surfaces of two tablets compressed at 5 kN and 30 kN are compared. At higher compressional forces, a uniform, flat, and smooth tablet surface is formed, but within this surface a single unchanged ascorbic acid crystal could be detected. Observation of a broken tablet (Fig. 24C), which was prepared at a high compressional force of 30 kN, reveals that the ascorbic acid crystal is totally fixed within a matrix of plastically...
Sorbitol can exist in four crystalline forms. Guyot-Hermann, Leblanc, and Draguet-Brugmans compared 11 commercially available varieties of sorbitol, and found three of these four forms to be present. y-Sorbitol was found to be the most useful as a tablet diluent. The method of manufacture has also been shown to affect tabletting properties, differences being attributed to variations in particle shape and surface properties. Spray-dried varieties of sorbitol are available as direct compression diluents which are claimed to have overcome problems associated with the different crystalline forms. ... [Pg.3681]


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