Sorbitol Instant

Fig. 11 Sugar alcohols. Mannitol, crystalline (A), mannitol, spray dried (B), and sorbitol-instant, spray dried (C).

Fig. 20 Interactive mixtures with sorbitol as a carrier. Sorbitol plus 16% micronized etilefrine HCl, part of the granule (A), sectional view from left showing the fine sorbitol needles and the micronized particles of etilefrine (B). Pure sorbitol instant (C), sorbitol plus 16% propranolol (D).

Fig. 24 Differences in the deformation behavior of substances during tableting demonstrated by sorbitol instant as an example for a plastically deforming substance and ascorbic acid as a more brittle one. Tablet compressed at 5 kN (10 mm in diameter) (A) and 30 kN (B). Inner part of a broken tablet showing an ascorbic acid crystal being totally embedded into plastically deformed sorbitol (C) and a crystal being partially removed from the sorbitol matrix through the break down of the tablet (D). A cracked ascorbic acid crystal in a sorbitol matrix (E).

Tablets. SEM was widely used to investigate the structure of tablets. An excellent review is presented by Hess. " Imaging of tablets is a useful tool to demonstrate differences in compression behavior of substances. Fig. 24 shows an example where the plastically deforming spray-dried sorbitol instant was compressed together with the more brittle ascorbic acid in one tablet. At low compressional force of 5 kN for a 10 mm tablet, the rectangular ascorbic acid crystals as well as the partially deformed sorbitol particles are visible (Fig. 24A). In Figs. 24A and B, the surfaces of two tablets compressed at 5 kN and 30 kN are compared. At higher compressional forces, a uniform, flat, and smooth tablet surface is formed, but within this surface a single unchanged ascorbic acid crystal could be detected. Observation of a broken tablet (Fig. 24C), which was prepared at a high compressional force of 30 kN, reveals that the ascorbic acid crystal is totally fixed within a matrix of plastically...

Starch and starch derivatives Sorbitol Instant Merck... 

Basedow, A.M. Moschl, G.A. Schmidt, P.C. Sorbitol instant, an excipient with unique tabletting properties. Drug Dev. Ind. Pharm. 1986,12 (11-13), 2061-2089. 

C PharmSorbidex-, E420 1,2,3,4,5,6-hexanehexol Liponic 70-NC Liponic 76-NC Meritol Neosorb-, sorbite D-sorbitol Sorbitol Instant-, Sorbogem. 

Basedow AM, Mbschl GA. Sorbitol instant - an excipient with unique tableting properties. Drug Dev Ind Pharm 1986 12 2061-2089. 

Burgess S. Sorbitol instant a unique excipient. Manuf Chem 1987 58(6) 55, 57, 59. 

Paracetamol, fine powdi Sucrose, fine powder. Sorbitol Instant (Merck). 

Instant sorbitol is made by spray drying a concentrated aqueous solution of sorbitol [2]. 

Various particle morphologies have been reported using scanning electron microscopy (SEM) [7,25,26]. The y-form can exhibit morphologies of dense irregularly shaped particles, or of needle-like particles that result in a more loose-knit matrix [7,25]. Instant sorbitol was found to be an... 

Photomicrographs taken at higher magnifications of representative surfaces of instant sorbitol and crystalline sorbitol particles are presented in Figure 2. For the instant sorbitol lot, the surface appears porous and comprised of needle-like particles. The surface of crystalline sorbitol, however, exhibits some roughness and some fine particles, but the overall surface is compact and non-porous. 

The floodability index was calculated from the dispersibility, cohesion, angle of fall, and flowability index parameters. The values for this property ranged from 55 to 76. The most floodable material was lot 4405K5, and the least floodable material lot was the instant sorbitol, which is in agreement with the flow index and the particle size data. The... 

It has also been reported that the tableting characteristics of instant sorbitol result from its unique particle morphology [28]. Disintegration of instant sorbitol model tablets was found to be slower than tablets prepared using lactose, but this parameter can be optimized by proper disintegrant selection. 

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