Sorbitex

Iron compounds for intramuscular administration are iron sorbitol-citric acid complex (iron sorbitex), iron dextran, iron glycerin-citric acid complex, and iron poljdso-maltose. The work on these formulations is largely old and has been reviewed in previous volumes in this series. 

Iron toxicity can be expected if the amount of free iron released into the plasma exceeds the plasma iron-binding capacity. This is more likely to occur when using iron sorbitol-citric acid complex (iron sorbitex), since the iron is less firmly bound than with iron dextran. Several conditions associated with low iron-binding capacity, such as malnutrition (kwashiorkor, malnutrition syndrome) and previous or simultaneous oral iron therapy appear to predispose to the development of these toxic reactions. In addition, folic acid deficiency has been reported to be a predisposing factor (SED-9, 516), the likely mechanism being altered iron utilization secondary to folic acid deficiency, which results in an increased saturation of ironbinding capacity. 

Urine can turn dark in color in the first 24 hours after parenteral iron injection. The reddish-brown color, which has been observed after the intramuscular injection of iron sorbitol-citric acid complex (SED-8, 515), is due to urinary excretion of part of the iron compound. It has to be distinguished from the black discoloration that may develop if urine of patients who have received iron-sorbitex is allowed to stand, assumed to be due to production of iron sulfide by bacterial growth. Phenomena of this kind are unhkely to occur after the... 

Iron Sorbitex, Gluciiol iron complex, compound... 

Iron sorbitex, USAN. Jectofer [1338-16-5] Haematinic. A colloidal soln. containing Fe(///), sorbitol and citrate stabiUsed with dextrin. 

Iron(/7) gluconate, G-250 Iron sorbitex, G-247 Ironate, G-250 Isatoribine, 1-47 Isepacin, G-226 Isepamicin, G-226... 

A case has been reported of a patient who, immediately after i.m. injection of 100 mg iron-sorbiteX, developed symptoms and signs of myocardial damage (58 ). The authors suggest that if the iron-binding capacity is exceeded, ionized iron is probably forced into the mitochondria of the cells, interrupting the electron transport of the respiratory chain. 

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