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Small molecule microarrays were also used to discover robotnikinin (Section 1.4), a ligand that binds to the extracellular Sonic Hedgehog (Shh) protein." Approximately 10000 diversity-oriented synthesis compounds and natural products were immobilised on a single microscope slide. The small molecule microarray was challenged with the 20kDa N-terminal fragment (ShhN) of Shh some structurally related macrocycles were identified as hits and, after... [Pg.17]

See other pages where Sonic hedgehog , synthesis is mentioned: [Pg.510] [Pg.848] [Pg.457] [Pg.77] [Pg.112] [Pg.341] [Pg.356]