Solvent order of addition

Variables in the condensation reaction include the temperature, nature of the solvent, order of addition (either chlorosilane to excess sodium or "inverse" addition, sodium to excess chlorosilane), and the rate of addition. A careful study of reaction variables by the Sandia group of Dr. John Zeigler(15) will be described in detail elsewhere in this volume. 

Regioselectivity is quite sensitive to reaction conditions (e.g. solvent, order of addition of the reactants, concentration, and... 

Regioselectivity is quite sensitive to reaction conditions (e.g. solvent, order of addition of the reactants, concentration, and temperature). For example, acetylation of naphthalene can be directed to produce either a 99 1 mixture of C-1 C-2 acetyl derivatives (by addition of a solution of arene and AcCl in CS2 to a slurry of AICI3 in CS2 at 0°C) or a 7 93 mixture (by addition of the preformed AcCl/AlCb complex in dichloroethane to a dilute solution of the arene in dichloroethane at rt). Similarly, acetylation of 2-methoxynaphthalene can be directed to produce either a 98 2 mixture of C-l C-6 acetyl derivatives (using the former conditions) or a 4 96 mixture (by addition of the arene to a solution of the preformed ACCI/AICI3 complex in nitrobenzene). Also, acetylation of 1,2,3-mesitylene can be directed to produce either a 100 0 mixture of C-4 C-5 isomers or a 3 97 mixture. ... 

E )eriment Al-0.05mol Did x 0.05mol Solvent Order of addition (solvent volume) Method of Isolation Yield Obseryed (g) Yield Calculated (g)... 

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