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Solution-phase synthesis target selection

Recombinant insulin precursor MI3 Study of the target protein per se and selection of appropriate binding sites Solid-phase combinatorial chemistry (64 ligands) solution-phase synthesis of a sub-library Affinity chromatography SPR 15,18,19... [Pg.46]

This section focuses on the construction of compound libraries by solid or solution-phase techniques targeted to discovering or optimising enzyme inhibitors. As in subsequent sections, the libraries will be presented in tabular form (Tables 3.1-3.4) and for each library the name, the generic structure, the size, the synthesis, the enzyme screen and the structure and potency of the most active member will be included. We have chosen to include in the tables only libraries for which biological data (Kj or IC50) has been given and in the text only selected libraries are discussed. [Pg.112]


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See also in sourсe #XX -- [ Pg.346 ]




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Phase selection

Phase selectivity

SYNTHESIS SOLUTIONS

Selected Syntheses

Selective targeting

Synthesis selectivity

Target selection

Target selectivity

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