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Solution phase synthesis, 21-amino acid synthetic protein

Solution Phase Synthesis of the Pulmonary Surfactant KL4 A 21 Amino Acid Synthetic Protein... [Pg.181]

The synthetic 21-amino acid polypeptide KL4 [(KL4)4K] was developed as a pulmonary surfactant to be used in treatment of respiratory distress syndrome (RDS) in infants (IRDS) and in adults (ARDS). KL4 is designed to contain intermittent hydrophobic (Leucine) and hydrophilic (Lysine) regions to mimic the structure of the natural surfactant protein B (SP-B). The solution phase synthesis of KL4 is a challenging task. The protection and deprotection patterns, the possibility of diastereomer formation in every coupling step, the solubility (or lack of it) of the different fragments and the isolation of intermediates are among the potential problems that face such a synthesis. The process research work resulted in a successful and efficient large scale synthesis of KL4 which will be discussed. [Pg.181]

See other pages where Solution phase synthesis, 21-amino acid synthetic protein is mentioned: [Pg.182]    [Pg.138]    [Pg.347]    [Pg.3545]    [Pg.63]    [Pg.243]    [Pg.50]    [Pg.5]    [Pg.913]    [Pg.18]    [Pg.49]    [Pg.85]    [Pg.94]    [Pg.322]    [Pg.7]    [Pg.3543]    [Pg.428]    [Pg.428]   
See also in sourсe #XX -- [ Pg.181 , Pg.182 , Pg.183 , Pg.184 , Pg.185 , Pg.186 , Pg.187 , Pg.188 , Pg.189 , Pg.190 , Pg.191 , Pg.192 , Pg.193 , Pg.194 , Pg.195 , Pg.196 ]



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Acids phase

Amino acids synthetic

Protein solutions

Proteins synthetic

SYNTHESIS SOLUTIONS

Synthesis amino acids

Synthetic phases

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