Solution conformation of biological

It has long been recognized that NMR cross relaxation data can provide information on the solution conformation of biological macromolecules, mainly through the inverse sixth power dependence of the cross-relaxation rates on internuclear distance. Only recently with the advent of sophisticated two-dimensional acquisition techniques has it become possible to attempt the a-priori determination of the solution conformation... [Pg.240]

This article presents the application of a novel technique, which combines the structural sensitivity of vibrational spectroscopy with the conformational sensitivity of chiroptical methods to study the solution conformation of biological molecules. Instrumental aspects, computational methods and spectral results for peptides and nucleic... [Pg.91]