Soluble aggregates, formation

There is much indirect evidence that the above hypothetical mechanism fits the behavior of the soy proteins. Wolf and Tamura (2), while studying the heat denaturation of native IIS soy protein, found that soluble aggregates are formed prior to the formation of insoluble precipitates. They proposed the following mechanism to explain their results. 

Catsimpoolas et al. (2) and Hermansson ( ) have found that the reaction leading to formation of the soluble aggregates is reversible. Recently, Takagi et al. ( ) found that hydrophobic interactions are primarily responsible for the formation of the soluble aggregates which are subsequently irreversibly insolu-bilized through intermolecular disulfide bond interchange. 

Amino acid-based norbomene random and block copolymers have been synthesized by Sanda, Masuda et al. [178]. The blocks were constructed with monomers containing either the ester or carboxyl amino acid forms, and C4 was used. While the random copolymers were partially soluble in acetone, the block copolymers were soluble through formation of reverse micelles (Scheme 24). Moreover, the diameter of these aggregates was around 100 nm as measured by DLS and AFM. Amino acid-based ROMP monomers with a different cyclic core, i.e., cyclobutenecarbonyl glycine methyl esters, were polymerized by Sampson et al., leading to head-to-tail-ordered polymers without stereocenters [179]. C6 was used and polydispersities between 1.2 and 1.6 were obtained. 

Ohno O, Kaizu Y, Kobayashi H (1993) J-aggregate formation of a water-soluble porphyrin in acidic aqueous media. J Chem Phys 99 4128-4139... 

Konno K, Jinno T, Kitahara A. Solubility, critical aggregating or micellar concentration and aggregate formation of non-ionic surfactants in non-aqueous solutions. J Colloid Interface Sci 1974 ... 

As discussed in the following sections, even soluble surfactants can form inhomogeneous adsorption layers. The origin of such inhomogeneities is not fully understood. It could be possible that it is a feature of mixed adsorption layers, formed by commercial surfactants of low purity or by mixtures of particular composition. Such domain-like structures could be formed due to remarkable differences in the interaction strength within the adsorption layer. The formation of 2- and 3-dimensionaI aggregates at interfaces is known from studies of insoluble monolayers (Mohwald et al. 1986 and Barraud et al. 1988, Vollhardt 1993). First dynamic models of aggregate formation in insoluble monolayers were theoretically described by Retter Vollhardt (1993) and Vollhardt et al. (1993). These simple and new, more... 

---