Solubilization lipid vehicles

A typical example of an ester acting as a penetration enhancer is isopropyl myristate. Isopropyl myristate might show a double action influence on the partition between vehicles and skin by solubilization and disruption of lipid packing, thus increasing the lipid fluidity... 

Lipids may be supplied either as lyophilized or dried powders, as liquids, or dissolved or suspended in an appropriate solvent. Dried powders are typically waxy or sticky in character, making aliquoting of the product troublesome. Lipid lyophilates can also be hygroscopic, thus presenting some difficulty for fluidized bed operations. Fluid bed applications however, may be successful if the concentration of lipid is held fairly low. Handling of lipid products in a liquid state allows for more accurate compormding. Solubilization vehicles may involve dissolution into either polar or non-polar... 

Lipid-Containing Solubilizing Vehicles in Capsules—One Solubilizing... 

Recent physical-chemical observations on native mammalian systems reveal that the proposed mixed micellar mechanism of lipid solubilization and transport in both bile and in upper small intestinal contents is incomplete [1,260-263]. Bile is predominantly a mixed micellar solution but, particularly when supersaturated with Ch, also contains small liquid-crystalline vesicles which, as suggested from model systems [239], are another vehicle for Ch and L transport. In dog bile which is markedly unsaturated with Ch [258], these vesicles exist in dilute concentrations and may be markers of the detergent properties of BS on the cells lining the biliary tree and/or related to the mode of bile formation at the level of the canaliculus. In human hepatic bile, which is generally dilute and markedly supersaturated with Ch, these vesicles may be the predominant form of Ch and L solubilization and transport [261]. If hepatic bile is extremely dilute, it is theoretically possible that no BS-L-Ch micelles may be present [268] all of the lipid content may be aggregated... 

---