Definitions solubility

Yazdanian, M., Briggs, K., Jankovsky, C., and Hawi, A., The "high solubility" definition of the current FDA guidance on biopharmaceutics classification system may be too strict for acidic drugs, Pharm. Res., 21, 293, 2004. 

Solubility is expressed as the concentration of a substance in a saturated solution at a defined temperature. The US Pharmacopeia (USP) gives the solubility definitions shown in Table 12-2. 

Yazdanian M, Briggs K, Jankovsky C, et al. The high solubility definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drags. Pharm Res 2004 21(2) 293-299. 

According to the solubility rules, all phosphates are insoluble (nickel is not a group lA element) and all chlorates are soluble. Thus, the solubility definition provides the following result ... 

This measurement provides a definition of the bitumen content in bitumen materials as the portion soluble in carbon disulfide (in France, in trichloroethylene, carbon tetrachloride or tetrachloroethylene). The method is defined by AFNOR NF T 66-012 or IP 47, or ASTM D 4 (the latter is not equivalent to the others). 

We suppose that the Gibbs dividing surface (see Section III-5) is located at the surface of the solid (with the implication that the solid itself is not soluble). It follows that the surface excess F, according to this definition, is given by (see Problem XI-9)... 

All colourless solids, which decompose on heating and therefore have no definite m.p.s. All insoluble in ether (like most polyhydroxy-compounds). All except starch are soluble in water and have a sweet taste. Starch as ordinarily supplied is insoluble in... 

The distillate may contain volatile neutral compounds as well as volatile acids and phenols. Add a slight excess of 10-20 per cent, sodium hydroxide solution to this distillate and distil until the liquid passes over clear or has the density of pure water. The presence of a volatile, water-soluble neutral compound is detected by a periodic determination of the density (see Section XI,2) if the density is definitely less than unity, the presence of a neutral compound may be assumed. Keep this solution Si) for Step 4. 

Equations 2 and 3 also stand as the definitions of and For sparingly soluble gases, however, p- ca so that from equation 1,... 

Cross-linked versions of water-soluble polymers swollen in aqueous media are broadly referred to as hydrogels (52) and have a growing commercial utility in such apphcations as oxygen-permeable soft contact lenses (qv) (53) (Table 4) and controUed-release pharmaceutical dmg deflvery devices (54). Cross-linked PVP and selected copolymers fit this definition and are of interest because of the following stmcture/performance characteristics ... 

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