Solubilisation of triglycerides

We propose that these triglycerides-enriched domains consist of folded bilayer units in the form of a hyperbolic bilayer. Evidence for such a structure comes from lipid phase studies of transitions from the La phase to a cubic phase accompan3dng solubilisation of triglycerides into the La phase [56]. A h3 erbolic bilayer domain of this type is consistent with the high-resolution NMR signals. 

Bile salts have most of the properties of an anionic detergent, forming micellar solutions above their critical micellar concentrations. They possess a low capacity for the solubilisation of non-polar substances but a high one for polar ones. The triglycerides of the dietary fats would thus be expected to be emulsified to a limited extent in the duodenum by bile salts, aided by the free fatty acids formed in the stomach and the other bile constituents. 

Emulsification/absorption of dietary lipid in the intestine. Bile acids are stored in the gallbladder and released into the duodenum when cholecys-tokinin is released. In the small intestine, bile acids help to solubilise monoglycerides and fatty acids which are formed as the result of the digestion of dietary triglyceride, thereby enhancing the absorption of lipids and the fat-soluble vitamins A, D, E and K. 

Cremophor EL is a polyoxyethylated castor oil containing approximately 40 oxyethylene groups to each triglyceride unit. It is used as a solubilising agent in the preparation of intravenous anaesthetics and other products. 

Fat emulsions are used to supply a large amount of energy in a small volume of isotonic liquid they supply the body with essential fatty acids and triglycerides. Fat emulsions for intravenous nutrition contain vegetable oil and phospholipid emulsifier. Several commercial fat emulsions are available, such as Intralipid, Lipiphysan, Lipofundin and Lipo-fundin S. They contain either cottonseed oil or soybean oil. In Intralipid, for example, purified egg-yolk phospholipids are used as the emulsifiers, and isotonicity is obtained by the addition of sorbitol, xylitol or glycerol. Intralipid has also been used as the basis of an intravenous dmg carrier, for example for diazepam (Diazemuls) and propofol (Diprivan), as an alternative to solubilisation in nonionic micellar systems such as Cremophor EL. 

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