Solid-Phase Organic Radiosynthesis with Carbon

3 SOLID-PHASE ORGANIC RADIOSYNTHESIS WITH CARBON-11 

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Owing to the short half-lives of the radioactive isotopes involved (e.g., t n of carbon-ll=20min, ty-i of fluorine-18 = 110min), radiopharmaceuticals for PET (and related SPECT) imaging are typically produced on-site daily or at facilities in close proximity to the PET imaging center. Radiopharmaceutical production typically requires trained radiochemists, with specific and expensive facilities. Moreover, the short-lived radionuclides involved means that radiochemical reactions must be fast, efficient, and amenable to automation, and new techniques that facilitate radiopharmaceutical production and the ability to meet clinical demand for PET tracers are in demand. Solid-phase synthesis is an attractive synthetic technique to the radiochemist as it bears many of these desirable characteristics. Despite this, solid-phase organic radiosynthesis (SPOR) is a relatively new... 

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