SOLID-PHASE ORGANIC RADIOSYNTHESIS

Owing to the short half-lives of the radioactive isotopes involved (e.g., t n of carbon-ll=20min, ty-i of fluorine-18 = 110min), radiopharmaceuticals for PET (and related SPECT) imaging are typically produced on-site daily or at facilities in close proximity to the PET imaging center. Radiopharmaceutical production typically requires trained radiochemists, with specific and expensive facilities. Moreover, the short-lived radionuclides involved means that radiochemical reactions must be fast, efficient, and amenable to automation, and new techniques that facilitate radiopharmaceutical production and the ability to meet clinical demand for PET tracers are in demand. Solid-phase synthesis is an attractive synthetic technique to the radiochemist as it bears many of these desirable characteristics. Despite this, solid-phase organic radiosynthesis (SPOR) is a relatively new 

Solid-Phase Organic Synthesis Concepts, Strategies, and Applications, First Edition. Edited by Patrick H. Toy and Yulin Lam. 

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SOLID-PHASE ORGANIC RADIOSYNTHESIS WITH FLUORINE-18 13.2.1 Radiolabeled Peptides with Fluorine-18... 

SOLID-PHASE ORGANIC RADIOSYNTHESIS WITH FLUORINE-18... 

Scheme 13.3. Solid-phase organic radiosynthesis of [ F]FDG according to Wadsworth et al. and Brady et al.

Solid-Phase Organic Radiosynthesis of -Amyloid PET Tracers... 

Scheme 13.9. Solid-phase organic radiosynthesis of NADHiubiquinone oxidoreductase inhibitors as PET tracers for brain tumors according to Cheesman and coworkers.

Scheme 13.11. Solid-phase organic radiosynthesis of carbon-11-labeled acyl chlorides according to Robins and Turton.

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