Solid phase analysis

The consequences of product accumulation on the structural and chemical properties of a reacting crystal have been examined by several authors. These can be analyzed from a perspective that focuses on molecular changes or from a crystal phase point of view. A molecular analysis focuses on local structural properties that affect the reaction mechanism [55,57,58]. A solid-phase analysis focuses on how a crystalline ensemble reacts to the changes in composition that occur as the reaction proceeds [59-61]. However, as suggested in Scheme 5, a separation... 

While the majority of attention in combinatorial syntheses has been on solid phase analysis, the use of traditional solution phase organic chemistry to form compound collections should not be disregarded. MS techniques are widely used for evaluation of mixtures produced by combinatorial chemistry (4). However, a potential problem with the MS methodology involves a situation when isomolecular weight compounds are present. The compounds can be stereoisomers, positional isomers or by chance identical molecular weight materials. In these cases, the identity of the substance as determined by MS can be ambiguous. 

Purdon and Slater (1946) give good accounts of the practical difficulties that may be encountered in applying both the wet-residues and synthetic complex methods of solid phase analysis. 

Solution concentration and solid phase analysis Measurement of the solution concentration of each co-crystal component when the solution is... 

FIG. 6 Kinetic analysis of solution-mediated phase transformation of in situ precipitated calcium oxalate trihydrate (COT) into calcium oxalate monohydrate (COM), (a) Solution analysis Variation of ion activity product vs. time, (b) Solid phase analysis Total crystal volume (curve 1) and volume fractions of COT (curve 2) and COM (curve 3) vs. time. 

---