Solid oligosaccharide library

Solid-phase approaches may ease the product isolation and purification in the generation of larger oligosaccharide libraries. However, solid-support oligosaccharide synthesis requires thorough... 

Scheme 6.192 shows the o-nitrobenzyl moiety used as a photolabile linker in the solid-phase oligosaccharide synthesis on a polystyrene (PS) support.1208 After the synthesis of the protected oligosaccharide 404, PS attached to the photoremovable group is removed by photolysis and the final product is obtained by hydrogenolysis. Such a strategy could be promising for combinatorial synthesis of oligosaccharide libraries. 

Figure 8.7. A true solid-phase oligosaccharide library [41], showing exponential increase in number of compounds with each reaction step. The library was screened for active compounds using a solid-phase, enzyme-linked assay and the components were identified using chemical coding.

As a consequence of the progress and success of diverse oligomer libraries, experts in combinatorial synthetic oligomers, glycopeptide and oligosaccharide libraries, RNA-and DNA-aptamers have each contributed their news in these fields, while novel experimental examples of the use of templates in combinatorial chemistry for the solid-phase synthesis of multiple core structure libraries provide some insight to praxis-relevant work. 

The advantage of solution phase approaches for constructing combinatorial libraries is the direct translation of known solution chemistry to library synthesis, versus the need to reengineer these chemistries to be compatible with the solid phase environment. Three approaches have been reported for generating solution phase oligosaccharide libraries [27-30]. The first reported strategy attempted to address one of the inherent challenges and costs associated with... 

P.H. Seeberger, Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries, Wiley, New York, 2004. 

Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries... 

The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries... 

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