Theophylline solid dispersions

Fassihi, Parker, and Pourkavoos used a combination of hydrophilic and lipophilic polymers to control the release rate. Thus, solid dispersions of theophylline were prepared by the fusion method using various ratios of PEG-6000, ethyl cellulose, and acrylic/ methacrylic esters. 

M. Moneghini, E Rubessa, R Rupena, and M. Zacchigna, Dissolution rates of theophylline from solid dispersions with monoethyl ester of poly(methylvinylether/ maleic anhydride), STP Pharma, 6 (6), 376-379,1990. 

Also known as bhara gum, the exudate from the incised trunk of some tropical trees of Terminalia genus (T. bellerica Roxb., T. catappa L., T. randii Baker f.), Combretaceae family, may be used in the formulation of some sustained release pharmaceutical forms famotidine microcapsules (ionic gelation technique) [296] dextromethorphan hydrobromide tablets obtained by direct compression, wet granulation and solid dispersion techniques [297] carvedilol (water insoluble) and theophylline (water soluble) tablets prepared by direct compression - Terminalia gum was assessed as controlled release matrix against xanthan gum and hydroxypropyl methylcellulose [298]. 

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