Solanum malacoxylon

Hypercalcaemia and soft-tissue calcification have been found in animals grazing on plants such as Cestrum diumum and Solanum malacoxylon, and attributed to the presence of a l,25-(OH)2D3-glycoside.453 The calcinogenic plant Trisetum flavescens causes severe calcification on ingestion, but the vitamin D3 species responsible has not been identified 454... 

Calcitriol (la,25-dihydroxycholecalciferol, vitamin D3, 105) (O Scheme 41) is involved in calcium metabolism. Glycosides of this compound occur in plants [200,201] and also as metabolites in mammal organisms. -Glucopyranosides of 105 linked to the C-1, C-3, or C-25 hydroxyfunctions were tested in vivo (rats) and compared with the aglycon. These glycosides occur as potential sources of vitamin D in plants, e. g., Solanum malacoxylon [200] where... 

Boland RL (1986) Plants as source if vitamin D3 metabohtes. Nutr Rev 44 1-8 Boland RL, Skliar MI, Norman AW (1987) Isolation of vitamin D3 metabohtes from Solanum malacoxylon leaf extracts incubated with ruminal fluid. Planta Med 53 161-164 Boland RL, Skhar MI, Curino A, Milanesi L (2003) Vitamin D compounds in plants. Plant Sd 164 357-369... 

Nicotiana. Vitamin as well as 25(OH)Dj and la,25(OH)jD3were identified in the leaves of N. glauca Graham (Skliar et al. 2000). Furthermore, 7-dehydrochole-sterol known as a precursor in human cholecalciferol biosynthesis could also be detected. Furthermore, this precursor was detected in Solanum glaucophyllum sub nom. S. malacoxylon which led to the assumption that the biosynthesis of cholecalciferol and its congeners in plants might proceed on a similar pathway to that in humans (Aburjai et al. 1996). 

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