Sodium tetrachloroaluminate Friedel-Crafts reaction

Molten sodium tetrachloroaluminate (a 1 1 mixture of NaCl and AICI3) is a good reaction medium for the Friedel-Crafts acylation reaction given in fig. 3.3 (Wade et al., 1979). Whereas the classical procedure for the synthesis of 1-indane from 3-phenylpropanoic acid consists of three reaction steps with a total reaction time of ca. six hours (Gattermann et al., 1982), the molten salt reaction is finished in five minutes and gives an even better yield (Wade et al., 1979). 

Molten sodium tetrachloroaluminate (a 1 1 mixture of NaCl and AICI3) is a good reaction medium for the Friedel-Crafts acylation reaction given in Eq. (3-3) [115],... 

One of the early examples of the use of sodium tetrachloroaluminate in intramolecular Friedel-Crafts acylation reactions involved the reaction shown in equation (49), in which P-(3-acenaphthoyl)propanoic acid was converted into perisuccinoylacenaphthene. The formation of the benzosuberanone ring system is particularly easy when electron-releasing substituents are present on the benzene ring. Under those cir-... 

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