Sodium channels, channeled biosynthesis

Schmidt JW, Catterall WA 1986 Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons. Cell 46 437-445... 

Voltage gated sodium channel (vgSCh) y-aminobutyric add (GABA) receptor/chloride ionophore complex chitin biosynthesis pathways mitochondrial respiratory chain and ryanodine receptor for insedicides. 

As with the biosynthesis of anandamide, the biosynthesis of 2-AG is also triggered by increases of intracellular calcium ions that result from neuronal activity. High frequency stimulation of neurons produced a fourfold increase of 2-AG accumulation compared with controls, and this was prevented by sodium ion channel blocking or removal of calcium ions (Stella, 1997). The concentration of 2-AG in depolarized neurons reached 1 to 2 pM, significantly higher than anandamide and sufficient to substantially activate CB1 (Stella, 1997). 

In isolated DRG neurons, H2S donor (sodium hydrosulflde NaHS) facilitated T-type calcium channel-dependent currents, and caused hyperalgesia, and this effect was blocked by a T-type channel inhibitor. More results are available about the peripheral effect of H2S. H2S biosynthesis is increased following IPL injection of carrageenan, local administration of NaHS induces a mechanical hypernociception, and the hyperalgesia was decreased by H2S synthesis inhibitor or by T-type... 

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