Sodium channel inhibitors

The sodium-channel inhibitor Amiloride is used for the treatment of chronic bronchitis, and the most frequently used anesthetic drug, lidocain, inhibits voltagegated sodium-channel a subunits, which mediate the pathophysiology of pain. 

Again, soft corals and gorgonians are a rich source of diterpenoids of 19 structural classes, some of which are specific to them (35, 36). Besides tobacco plants, cembranoid diterpenes are limited to soft corals. Lophotoxin (126) isolated from sea whips of the genus Lophogorgia is a sodium channel inhibitor (3). Xenicin (127) from the soft coral Xenia elongata and briarein A (128) from the gorgonian Briareum asbestinum represent non-cembranolide diterpenes. Diterpenoids of these classes show antimicrobial, cytotoxic, and insecticidal activities. 

The synthesis of sodium channel inhibitor 1 [82] illustrates the utility of the /V-oxide strategy by using it not only to form the biaryl carbon-carbon bond, but also to form the C4 carbon-nitrogen bond. Diaryl ether 3, prepared by a copper catalyzed cross-coupling of 4-fluorophenol and l-bromo-4-iodobenzene [83], was coupled... 

Sodium Channel Inhibitor and Antimalarial Agent (C-H Arylation of Pyridines at the C2 Position)... 

Yanagawa, Y, Abe, T., Satake, M., Odani, S., Suzuki, J. and Ishikawa, K. 1988. A novel sodium channel inhibitor from Conus geographus Purification, structure, and pharmacological properties. Biochemistry 21 6256-6262. 

---