SnoRNPs small nucleolar

NAD+ nicotinamide adenine dinucleotide snoRNP small nucleolar ribonucleoprotein... 

Finally, a large variety of proteins contribute to the assembly and maturation of the telomerase RNP, and these vary much more in evolution than TERT and the other proteins listed above. Budding yeast telomerase RNA is an RNA polymerase 11 transcript, and its intracellular transport and assembly are mediated by the same Sm proteins found in the small nuclear RNPs involved in RNA splicing [27]. Current evidence suggests that the RNA may be made in the nucleus, exported to the cytoplasm to pick up protein components, and then reimported into the nucleus where it functions [28, 29]. Human telomerase RNA, also a pol II transcript, has a snoRNP (small nucleolar RNP) domain, appears to be matured in the nucleolus, and binds dyskerin and other snoRNP proteins [30, 31]. Defects in the RNA or the dyskerin protein that interrupt this maturation can lead to a human disease, dyskeratosis congenita [30, 32]. Ciliate telomerase RNA is transcribed instead by pol III and, at least in Euplotes, is bound by a... 

Small interfering RNA, see siRNA Small molecule therapeutic target (SMT) 104 Small nucleolar RNA, see snoRNA Small nucleolar RNP, see snoRNP Small organic molecules, in disease targeting 1275... 

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