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SMRT sequencer

SMRT sequencer is a variation on SBS using a sequencing chip containing thousands of zero-mode waveguide (ZMW) detectors each with a single DNA polymerase attached at the bottom of its detection zone. First, fluorescent markers specific to each type of dNTP are attached to terminal phosphates. Next the sequencing reaction is initiated, and each labeled dNTP to be incorporated diffuses into the vicinity of the DNA polymerase within the... [Pg.82]

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