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Smooth Muscle Myosin Phosphatase

Thus there is ample precedence for regulation of phosphatase activity. The challenge for future research is to determine if the smooth muscle myosin phosphatase is regulated, and if so, how this mechanism integrates with the overall contraction-relaxation cycle of smooth muscle. [Pg.133]

Smooth muscle myosin phosphatase contains tree subunits, a 110-130 kDa myosin phosphatase targeting and regulatory subunit (MYPT1), a 37 kDa catalytic subunit (PP-1C) and a 20 kDa subunit of unknown function. [Pg.799]

Takai, A., Bialojan, C., Troschka, M., and Ruegg, J.C. 1987. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin. FEES Letts 217, 81-84. [Pg.221]

Hirano K., Phan B.C., Hartshorne D.J. (1997) Interactions of the subunits of smooth muscle myosin phosphatase. J Biol Chem 272 3683-3688... [Pg.126]

Shimizu H, Ito M, Mi hara M, Ichikawa K, Okubo S, Konishi T, Naka M, Tanaka T, Hirano K, Hartshorne DJ, et al (1994) Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase. J Biol Chem 269 30407-30411 Shirazi A, lizuka K, Fadden P, Mosse C, Somlyo AP, Somlyo AV, Haystead TA (1994) Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle. J Biol Chem 269 31598... [Pg.139]

Hirano K, Phan BC, Hartshorne DJ (1997) Interactions of the subunits of smooth muscle myosin phosphatase. J Biol Chem 272 3683-3688 Hori M, Sato K, Miyamoto S, Ozaki H, Karaki H (1993) Different pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle. BrJ Pharmacol 110 1527-1531... [Pg.227]

Ichikawa K, Hirano K, Ito M, Tanaka J, Nakano T, Hartshorne DJ. (1996a) Interactions and properties of smooth muscle myosin phosphatase. Biochemistry 35 6313-6320... [Pg.227]

Sobieszek, A. Borkowski, J. Babiychuk, V.S. Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex. J. Biol. Chem., 272, 7034-7041 (1997)... [Pg.48]

Figure 6.10. Calcium-dependent signalling by adrenergic receptors. a p-Adrenergic receptors activate adenylate cyclase. cAMP activates protein kinase A (PKA). In heart muscle, PKA phospho-rylates several Ca transporters and charmels, so that the amount of Ca available for contraction is increased. PL Phospholam-ban SERCA SR/ER Ca transporter, b In smooth muscle, myosin activation in works by way of phosphorylation, which is performed by myosin light chain kinase (MLCK). Inactivation is accomplished by myosin light chain phosphatase (MLCP). c aj-Adrenergic receptors stimulate phospholipase C, which releases inositoltriphosphate (IP3). IP3 binds to a cognate ligand-gated Ca chaimel in the ER and releases Ca, which with calmodulin activates MLCK. Figure 6.10. Calcium-dependent signalling by adrenergic receptors. a p-Adrenergic receptors activate adenylate cyclase. cAMP activates protein kinase A (PKA). In heart muscle, PKA phospho-rylates several Ca transporters and charmels, so that the amount of Ca available for contraction is increased. PL Phospholam-ban SERCA SR/ER Ca transporter, b In smooth muscle, myosin activation in works by way of phosphorylation, which is performed by myosin light chain kinase (MLCK). Inactivation is accomplished by myosin light chain phosphatase (MLCP). c aj-Adrenergic receptors stimulate phospholipase C, which releases inositoltriphosphate (IP3). IP3 binds to a cognate ligand-gated Ca chaimel in the ER and releases Ca, which with calmodulin activates MLCK.
Protein phosphatases (PP) are divided into phos-phoserine/threonine (SerZThr)-specific and phospho-tyrosine (Tyr)-specific enzymes based on the distinct specificity toward the phosphorylated residues. Smooth muscle myosin is phosphorylated at Ser 19... [Pg.131]

Pato and coworkers (Pato and Adelstein, 1983 Pato and Kerc, 1985, 1986) separated and purified four smooth muscle protein phosphatases, identified as SMP-I, SMP-II, SMP-III, and SMP-IV. SMP-I and SMP-II dephosphorylated isolated LC20, and these two enzymes were classified as PP2A and PP2C, respectively (Pato and Adelstein, 1983). SMP-III and SMP-IV dephosphorylated both isolated LC20 and intact myosin, and these enzymes were purified and characterized (Pato and Kerc, 1985 Tulloch and Pato, 1991). SMP-IV was composed of 40- and 58-kDa subunits and eluted... [Pg.135]

Nomura M, Stull JT, Kamm KE, Mumby MC (1992) Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A. Biochemistry 31 11915-11920... [Pg.135]

Okubo S, Ito M, Takashiba Y, Ichikavra K, Miyahara M, Shimizu H, Konishi T, Shima H, Nagao M, Hartshorne DJ, et al (1994) A regulatory subunit of smooth muscle myosin bound phosphatase. Biochem Biophys Res Commun 200 429-434... [Pg.136]

Sobieszek A, Babiychuk EB, Ortner B, Borkowski J (1997a) Purification and characterization of a kinase-associated myofibriOar smooth muscle myosin light chain phosphatase possessing a calmodulin-targeting subunit. J Biol Chem 272 7027-7033... [Pg.141]

Tokui T, Brozovich, F, Ando S, Ikebe M (1996) Enhancement of smooth muscle contraction with protein phosphatase inhibitor 1 Activation of inhibitor 1 by cGMP dependent protein kinase. Biochem Biophys Res Commun 220 777-783 Tdrbk K, Trentham DR (1994) Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(Nd -diethylamino)phenyl]-l,3,5-triazin-4-yl]calmodulin interactions with smooth muscle myosin light chain kinase and derived peptides. Biochemistry 33 12807-12820... [Pg.143]

See other pages where Smooth Muscle Myosin Phosphatase is mentioned: [Pg.265]    [Pg.133]    [Pg.234]    [Pg.84]    [Pg.143]    [Pg.201]    [Pg.211]    [Pg.216]    [Pg.216]    [Pg.218]    [Pg.218]    [Pg.265]    [Pg.133]    [Pg.234]    [Pg.84]    [Pg.143]    [Pg.201]    [Pg.211]    [Pg.216]    [Pg.216]    [Pg.218]    [Pg.218]    [Pg.43]    [Pg.126]    [Pg.624]    [Pg.57]    [Pg.4]    [Pg.133]    [Pg.140]    [Pg.328]    [Pg.120]    [Pg.121]    [Pg.124]    [Pg.133]    [Pg.134]    [Pg.138]    [Pg.211]    [Pg.219]    [Pg.226]    [Pg.227]   


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