Smith rhazinilam synthesis

In the three different approaches envisaged for the total syntheses of rhazinilam, the construction of the pyrrole ring was operated in two different manners a Knorr-type reaction in the Smith synthesis and a 1,5-electrocyclization of an allyl-iminium compound in the Sames and Magnus syntheses. 

Soon after the structure elucidation of rhazinilam, Smith and coworkers published its semi-synthesis and racemic total synthesis in the same report [62]. The total synthesis, Fig. (30), started with a Knorr-type... 

The structure elucidation of rhazinilam (172) by spectral and chemical means (81) and by X-ray crystallography (82) was discussed in Section II,F,3. In addition, a partial synthesis from (+)-l,2-dehydroasidosper-midine (171) was described (84). Smith and co-workers have also described an elegant total synthesis of rhazinilam (172) (84). 

---