Smart dmg

Shawver, L., D. Slamon, and A. Ullrich. 2002. Smart dmgs tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1 117-123. 

Thermoresponsive polymers are promising for biomedical applications, including as smart dmg/gene delivery systems, injectable tissue engineering scaffolds, and cell culture and separation sheets/ However, either the most frequently studied thermoresponsive polymers such as poly(N-isopropylacrylamide) (PNlPAAm), oligopoly(ethylene glycol), poly(N,N -diethylacrylamide), and poly(2-carboxyisopropylacrylamide) are non-degradable or the lower critical solution temperature (LCST) cannot be tuned. 

The terminology describing dmg delivery and targeting is extensive and ever-growing. Systems are diversely referred to as controlled release , sustained release , zero-order , reservoir , monolithic , membrane-controlled , smart , stealth etc. Unfortunately, these terms are not always used consistently and, in some cases, may even be used inaccurately. For clarity and consistency, some common terms used in this book are defined as follows ... 

Recent advances in biological and chemical sciences have led to the development of various Smart technologies to ensure more effective dmg delivery and targeting of dmgs to specific sites within the body. Such approaches include the use of ... 

Smart J, Berg E, Nerbrink O, Zuban R, Blakey D, New M. TouchSpray technology Comparison of the droplet size measured with cascade impaction and laser diffraction. In Respiratory Dmg Delivery V Dalby RN, Byron PR, Farr SJ, eds. Interpharm Press Phoenix, AZ, 2002 525-532. 

Caponi PF, Ulijn RV (2013) Enzyme-responsive dmg-deliveiy systems. In Smart materials for drug delivery. Royal Society of Chemistry, UK... 

The unique properties of pH-responsive polymers arise from the facile pH adjustment, which induces ionic interaction and hydrogen bonding, resulting in a reversible microphase separation or self-organization phenomenon. Thus, pH-responsive polymeric systems provide the possibility of preparation of smart functional materials that can be used for potential therapeutic applications, for example, controlled dmg delivery based on pH-triggered release. 

Whelan, J., 2002. Smart bandages diagnose wound infection. Dmg Discov. Today 7, 9-10. Wikltmd, U., Karlsson, M., Ostlund, N., Berglin, L., Lindecrantz, K., Karlsson, S., Sandsjo, L., 2007. Adaptive spatio-temporal filtering of disturbed ECGs a multi-channel approach to heartbeat detection in smart clothing. Med. Bio. Eng. Comput. 45, 515-523. 

Carbon nanotubes are the subject of many research studies from drug delivery systems to many other medical applications. Only a few references and examples have been mentioned here. This dmg delivery application by CNTs constitutes in itself the wide potential of fibrous material for smart implantable medical device designing, going beyond just the biological response impact and including physical and mechanical features. 

James HP, John R, Alex A, Anoop KR. Smart polymers for the controlled delivery of dmgs. ActaPharm Sin B. 2014 4(2) 120-7. 

Stimuli-responsive polymers (mostly cross-Unked polymers that change there properties in dependence on the environment, possible applications in dmg delivery systems, smart surfaces for cell culture and regenerative medicine, sensors and actuators),... 

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