Small Leucine-Rich Proteoglycan

Leucine-rich repeats represent binding motifs found in a wide variety of both plant and mammalian proteins (Kobe and Kajava, 2001). These are involved in a multitude of protein-protein interactions. The sequence of porcine ribonuclease inhibitor, for example, displays a leucine-rich repeat (LRR) of length 27-29 residues that occurs 15 times in tandem (Fig. 9). Likewise, the family of small leucine-rich proteoglycans that includes biglycan, decorin, epiphycan, fibromodulin, keratocan, and lumican... 

Decorin is a small, leucine-rich proteoglycan and one of the many extracellular matrix (ECM) compounds. It interacts closely with the D and E bands of type 1 collagen and increases collagen s tensile strength.39,40 In rats with subcutaneously implanted devices, we found that the decorin was highly expressed at the middle and later stages of the foreign body reaction.17... 

R.V. lozzo. 1999. The biology of small leucine-rich proteoglycans Functional network of interactive proteins J. Biol. Chem. 274 18843-18846. (PubMed)... 

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Vuillermoz B, Khoruzhenko A, D Onofrio ME, Ramont L, Venteo L, Perreau C, Antonicelli F, Maquart EX, Wegrowski Y. The small leucine-rich proteoglycan lumican inhibits melanoma progression. Exp Cell Res 2004 296 294-306. 

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