Small intestine biopsy

B2. Baker, S. J., and Hughes, A., Multiple-retrieving small-intestinal biopsy tube. Lancet ii, 686-687 (1960). 

Shiner, M., Small intestinal biopsy diagnostic and research value. Proc. Roy. Soc. Med. 52, 10-14 (1959). 

A small-intestinal biopsy is necessary to confirm the diagnosis of celiac disease (Dickson et ah, 2006 Flaines et ah, 2008). tiowever, the advent of... 

We had hypothesized that a possible mechanism leading to an attenuated response to an acute fat load of saturated fat might be a temporary retention of triglycerides in the intestinal mucosa during the process of chylomicron formation and release. In order to evaluate that possibility we took small intestinal biopsies via an upper endoscopy 5 h after the beginning of the fat load. 

Fontaine, J. L., and Navarro, J., 1975, Small intestinal biopsy in cow s milk protein allergy in infancy. Arch. Dis. Child. 50 357. 

Diagnosis of a malabsorption syndrome is based on the results of absorption tests such as xylose absorption, fat absorption balance study, the Schilling test for vitamin 6-12 absorption, and the folic acid test. Also gastrointestinal x ray studies, small intestine biopsy, prothrombin time, and serum levels of vitamin A are useful diagnostic tools. 

Biopsy Small intestinal mucosa Normal Normal ladder" appearance Abnormal... 

Shiner, M., Coeliac disease histopathological findings in the small intestinal mucosa studied by a peroral biopsy technique. Gut 1, 48-54 (1960). 

Peptic ulceration occurs as an acute or chronic non-traumatic epithelial breach typically in the gastric or duodenal mucosa, but also in the oesophagus (see above) and occasionally in the small intestine with the Zollinger-Ellison syndrome of gastrin overproduction or with an acid-secreting Meckel s diverticulum. Symptoms overlap with those of non-ulcer dyspepsia and cancer and the diagnostic cornerstone is endoscopy. Biopsy may be necessary to distinguish ulcer from cancer. 

Phosphonoformic acid (Foscarnet), an antiviral drug, which consists of carboxylic acid and phosphate linked together, was shown to be absorbed in the small intestine by the phosphate carrier-mediated mechanism [154], The transport of folic acid was investigated in biopsy specimens of intestinal mucosa from healthy volunteers. A pH-dependent, active transport of folic acid was found in the proximal small intestine, whereas in the mucosa of the colon, folic acid uptake was driven by a facilitated diffusion, mediated by a low-affinity carrier [155]. The existence of folate receptors in the human colonic mucosa is logical due to the large amounts of folic acid produced by the colonic flora [145],... 

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