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Small heterodimer partner

The role of bile acids in regulation of ASBT is complicated by species differences, with no effect in rats but showing negative feedback in mice and humans.This negative feedback is mediated by FXR and small heterodimer partner (SHP) causing repression of the RAR/RXR activation of ASBT. ... [Pg.33]

Bile acids and metabolites are endogenous PXR ligands that activate PXR to metabolize bile acids [49]. This may be a mechanism for detoxifying bile acids in the liver and intestine [50]. Bile acids activate farnesoid X receptor (FXR), which induces expression of small heterodimer partner (SHP), an atypical orphan receptor that lacks the DBD. SHP then inhibits transactivation of CYP7A1 gene by orphan... [Pg.171]

Li, T. and Chiang, J. Y. (2006) Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab. Dispos. 34, 756-764. [Pg.180]

Eloranta, J. J., Jung, D., and Kullak-Ublick, G. A. (2006) The human N a+- tau roc hoi ate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor- gamma coactivator-1 alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol. Endocrinol. 20, 65-79. [Pg.291]

Trauner, M. (2007) A little orphan runs to fat the orphan receptor small heterodimer partner as a key player in the regulation of hepatic lipid metabolism. Hepatology 46, 1-5. [Pg.294]

Miao J, Choi SE, Seok SM, Yang L, Zuercher WJ, Xu Y Willson TM, Xu HE, Kemper JK (2011) Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Mol Endocrinol 25 1159-1169... [Pg.743]

See other pages where Small heterodimer partner is mentioned: [Pg.5]    [Pg.114]    [Pg.580]    [Pg.2213]    [Pg.180]    [Pg.348]    [Pg.435]    [Pg.435]    [Pg.438]    [Pg.367]    [Pg.624]    [Pg.5]    [Pg.114]    [Pg.580]    [Pg.2213]    [Pg.180]    [Pg.348]    [Pg.435]    [Pg.435]    [Pg.438]    [Pg.367]    [Pg.624]    [Pg.201]    [Pg.669]    [Pg.193]    [Pg.97]    [Pg.92]    [Pg.3266]    [Pg.83]    [Pg.1468]   
See also in sourсe #XX -- [ Pg.367 ]



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