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UCHs are cysteine proteases in that the critical residue in the catalytic site is a cysteine. In addition, histidine and aspartate residues are critical for catalytic activity. All UCHs contain these residues even if they do not share a high degree of homology elsewhere in the sequence. For example, the Aplysia UCH (Ap-uch) critical for the induction oflong-term facilitation has only 39% homology to its human counterpart UCH-Lf. Ap-uch and UCH-Ll both contain the catalytic cysteine, histidine, and aspartate residues at similar positions in the molecule. UCHs cleave small peptide chains linked to the C-terminus of ubiquitin. UBPs can cleave the isopeptide bond between ubiquitins in a polyubiquitin chain and the isopeptide bond between the ubiquitin and the substrate. [Pg.716]

A8. The Helmholtz elastic free energy relation of the composite network contains a separate term for each of the two networks as in eq. 5. However, the precise mathematical form of the strain dependence is not critical at small deformations. Although all the assumptions seem to be reasonably fulfilled, a simpler method, which would require fewer assumptions, would obviously be desirable. A simpler method can be used if we just want to compare the equilibrium contribution from chain engangling in the cross-linked polymer to the stress-relaxation modulus of the uncross-linked polymer. The new method is described in Part 3. [Pg.446]

Hartree-Fock orbitals are used. The contributions from these clusters are exactly equal to zero when Brueckner orbitals are usedso It is now also understandable that all products containing such as t t, t t k etc. will be small. Generally, the effect of linked tri-excited clusters as well as that of linked tetra-excited clusters is small. (The calculations demonstrating these effects will be discussed in Section VI.G.) It is possible to state that from three-electron clusters upwards the contribution to the correlation energy coming from linked clusters decreases rapidly. This is also understandable due to the fact that these contributions first appear in terms of higher orders in the perturbation expansion, which is demonstrated in Table 1. From the above discussion it is possible to conclude that the most important clusters are... [Pg.124]

Hair is composed of approximately 65 to 95% protein, 1 to 9% lipid, and small quantities of trace elements, polysaccharides, and water. - - The majority of hair protein is often referred to as keratin, which is a general term used to describe aggregates of protein with low or high sulfur content. These proteins are synthesized in the keratogenous zone of the hair follicle as matrix cells move upward from the hair bulb to form layers of the hair shaft. The cuticle, cortex, and medulla are comprised largely of keratin, although it is structurally different in each layer. Keratin in the exocuticle contains a high concentration of cysteine, which forms disulfide bonds which link the A-layer to the exocuticle, and this makes the cuticle... [Pg.71]


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