Sliding-filament theory

Development of the Sliding Filament Theory of Muscle Contraction... 

DEVELOPMENT OF THE SLIDING FILAMENT THEORY OF MUSCLE CONTRACTION... 

Describe the sliding filament theory of skeletal muscle contraction... 

The mechanism of skeletal muscle contraction is described by the Sliding Filament Theory (see Figure 11.2). This mechanism begins with the "priming ... 

A. Huxley and Niedergerke, H.E.Huxley and Hanson. The sliding filament theory of muscle contraction. 

Our thesis in this review is that an understanding of structure leads to an understanding of function. But from this account of advances in the areas of tropomyosin, troponin, and muscle regulation, it should be evident that this path is not always straightforward. Of course, general ideas about function often spring from relatively low-resolution information. This was certainly true for the sliding filament theory of muscle... 

Wong YK (1973) Myocardial mechanics application of sliding-filament theory to isovolumic contraction of the left ventricle. J Biomechanics 6 565-581... 

From J. L. Krans. The Sliding Filament Theory of Muscle Contraction. 2010. Nature Ed. 3(9), p. 66. 

Somewhat similar considerations were also applied to acto-myosin systems, for which enhanced fluidization was predicted due to actin-driven sliding of filaments.For actin networks, it has long been known that the addition of myosin motors can cause network contraction and eventually a macroscopic phase separation, a process dubbed super-precipitation. Under certain conditions, however, enhanced fluidization due to an increased rate of stress relaxation was foimd in solutions of non-CTOss-linked actin that was activated by minifilaments of skeletal muscle myosin II. The gels were foimd to soften at low frequencies. This can be explained by an increase in the rate of stress relaxation in the entangled networks when motors actively slide the filaments arormd the obstacles. This sliding can also lead to the formation of bundled or oriented/polar-ized states of actomyosin gels. There bave been a number of hydrodynamic-like theories developed for such fluidlike active gels. "... 

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