Serotonin sleep-wake

Cape EG and Jones, BE (1998) Differential modulation of high-frequency gamma-electroencephalogram activity and sleep-wake state by noradrenaline and serotonin microinjections into the region of cholinergic basalis neurons. J. Neurosci. 18 2653-2666. 

Portas, CM, Bjorvatn, B and Ursin, R (2000) Serotonin and the sleep-wake cycle special emphasis on microdialysis studies. Prog. Neurobiol. 60 13-35. 

Iwakiri, H., Matsuyama, K. Mori, S. (1993). Extracellular levels of serotonin in the medial pontine reticular formation in relation to sleep-wake cycle in cats a microdialysis study. Neurosci. Res. 18, 157-70. 

Koella has reviewed the evidence implicating the involvement of serotonin in the sleep-wake cycle but the involvement of specific serotonin receptor subtypes in sleep mechanisms is unclear. Experimental evidence suggests that 5-HTia agonists delay the onset of REM sleep while 5-HT2 antagonists suppress REM and have variable effects on non-REM sleep. 

F]Setoperone Serotonin 5-HT2a receptors Sleep-wake cycle... 

Melatonin is /V-acetyl-5-methoxytryptamine (Figure 16-2), a simple methoxylated and /V-acetylated product of serotonin found in the pineal gland. It is produced and released primarily at night and has long been suspected of playing a role in diurnal cycles of animals and the sleep-wake behavior of humans. 

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