Sleep 114 insight

These insights into the structure of sleep and the neurobiological processes underlying it have yielded several targets for therapeutic intervention and provided novel methods by which to assess the differential effects of hypnotics on sleep-relevant neural circuits. 

There is no substitute for the chemist s intuition. The bench chemist should personally perform the primary analysis of the theoretical data and possibly the data generation itself, as long as the chemist understands that this method is not a miracle solution (and will not replace him or her). Ownership of the problem will often mean that the bench scientist is eating, sleeping and drinking the problem. This is the person who has the most insight into the problem and this is the person you want to look at the molecular graphics and the probe surfaces. 

Daley J. (2003). A Role for Dopamine in the Basal Ganglia in Sleep-Wake Regulation Insights from the MFTP-Treated Primate. Atlanta, GA Emory University. 

Miller JD, Morin LP, Schwartz WJ, Moore RY1996 New insights into the mammalian circadian clock. Sleep 19 641—667... 

Here again we see that subjective experience is a relatively weak but still informative source of mechanistic and functional insight. Consider the case of sleep following excessive—and therefore novel—daytime experiences like deep sea fishing (for landlubbers) and downhill ski-... 

Participants were driven home after this. They were given a sedative, which they might take if they experienced any difficulty in sleeping. In many cases, however, they preferred to stay up until well after midnight, continuing to work on insights and solutions discovered earlier in the day. 

Carskadon MA, Acebo C. Regulation of sleepiness in adolescents update, insights, and speculation. Sleep 2002 25(6) 606-614. 

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