Skin-3 bioassay systems

SENCAR mouse skin tumorigenesis bioassay system, OKNL/TM-9752, AD-A159 728, Oak Ridge... 

In an initiation-promotion skin bioassay conducted at New York University Medical Center (12), 69.0 mg of DBCP was applied to the skin of female mice, followedTy repeated application of phorbol myri state acetate three times weekly for 499 days. The most significant finding from this study was the occurrence of lung papillomas and squamous cell carcinomas of the forestomach indicating that the occurrence of stomach tumors in the oral studies may be systemic and not merely related to an irritant effect at the site of application. 

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